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A label free chemoproteomic-based platform to disclose cannabidiol molecular mechanism of action on chronic myelogenous leukemia cancer cells

The discovery of the interactome of cannabidiol (CBD), a non-psychoactive cannabinoid from Cannabis sativa L., has been here performed on chronic myelogenous leukemia cancer cells, using an optimized chemo-proteomic stage, which links Drug Affinity Responsive Target Stability with Limited Proteolysi...

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Principais autores: Sara Ceccacci, Lorenzo Corsi, Lucio Spinelli, Clarissa Caroli, Matilde Marani, Lisa Anceschi, Matteo Mozzicafreddo, Federica Pellati, Maria Chiara Monti
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-01-01
Serier:Heliyon
Fag:
Cannabidiol
Chronic myelogenous leukemia
Drug Affinity Responsive Target Stability
Limited proteolysis
Chemo-proteomics
Mass spectrometry
Online adgang:http://www.sciencedirect.com/science/article/pii/S2405844024002275
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