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Differential Effects of Tra2ß Isoforms on HIV-1 RNA Processing and Expression.

Balanced processing of HIV-1 RNA is critical to virus replication and is regulated by host factors. In this report, we demonstrate that overexpression of either Tra2α or Tra2β results in a marked reduction in HIV-1 Gag/Env expression, an effect associated with changes in HIV-1 RNA accumulation, alte...

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Autors principals: Craig Platt, Maria Calimano, Josip Nemet, Jodi Bubenik, Alan Cochrane
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2015-01-01
Col·lecció:PLoS ONE
Accés en línia:http://europepmc.org/articles/PMC4430212?pdf=render
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