An international, double-blind, randomized, placebo-controlled clinical trial of adjunctive trimetazidine to treat people with bipolar depression (the TIDE trial) protocol

Abstract Background Bipolar disorder is dominated by the depressive phase, and its treatment represents the greatest unmet need in mood disorders. Converging evidence indicates that bipolar depression is characterized by reduced mitochondrial function compared to the euthymic phase, with the severit...

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প্রধান লেখক:	Jee Hyun Kim, Chun Hui J. Park, Preethi V. Reddy, Sourav Khanra, Shyam Sundar Arumugham, Ganesan Venkatasubramanian, Monojit Debnath, Rashmi Arasappa, Melanie M. Ashton, Bruna Panizzutti, Alyna Turner, Varshitha Tholasappa, Devangi Shukla, Sachin Tudur Sadashiva, Justin Raj, Sudhakar Dombale, Olivia Dean, Mohammadreza Mohebbi, Eduard Vieta, Isabella Pacchiarotti, Shreekantiah Umesh, Ken Walder, Lakshmi Yatham, Ji Hyun Baek, Nishant Goyal, Y. C. Janardhan Reddy, Muralidharan Kesavan, Michael Berk
বিন্যাস:	Artigo
ভাষা:	Inglês
প্রকাশিত:	BMC 2026-04-01
মালা:	BMC Psychiatry
বিষয়গুলি:	Energy Mitochondria Depression Metabolism Bioenergetics Drug repurposing
অনলাইন ব্যবহার করুন:	https://doi.org/10.1186/s12888-026-08026-9
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