An international, double-blind, randomized, placebo-controlled clinical trial of adjunctive trimetazidine to treat people with bipolar depression (the TIDE trial) protocol

Abstract Background Bipolar disorder is dominated by the depressive phase, and its treatment represents the greatest unmet need in mood disorders. Converging evidence indicates that bipolar depression is characterized by reduced mitochondrial function compared to the euthymic phase, with the severit...

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Principais autores:	Jee Hyun Kim, Chun Hui J. Park, Preethi V. Reddy, Sourav Khanra, Shyam Sundar Arumugham, Ganesan Venkatasubramanian, Monojit Debnath, Rashmi Arasappa, Melanie M. Ashton, Bruna Panizzutti, Alyna Turner, Varshitha Tholasappa, Devangi Shukla, Sachin Tudur Sadashiva, Justin Raj, Sudhakar Dombale, Olivia Dean, Mohammadreza Mohebbi, Eduard Vieta, Isabella Pacchiarotti, Shreekantiah Umesh, Ken Walder, Lakshmi Yatham, Ji Hyun Baek, Nishant Goyal, Y. C. Janardhan Reddy, Muralidharan Kesavan, Michael Berk
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-04-01
coleção:	BMC Psychiatry
Assuntos:	Energy Mitochondria Depression Metabolism Bioenergetics Drug repurposing
Acesso em linha:	https://doi.org/10.1186/s12888-026-08026-9
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