E‐selectin affinity glycoproteomics reveals neuroendocrine proteins and the secretin receptor as a poor‐prognosis signature in colorectal cancer

Colorectal cancer (CRC) cells express sialylated Lewis antigens (sLe), crucial for metastasis via E‐selectin binding. However, these glycoepitopes lack cancer specificity, and E‐selectin‐targeted glycoproteins remain largely unknown. Here, we established a framework for identifying metastasis‐linked...

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Autori principali:	Sofia Cotton, Dylan Ferreira, Marta Relvas‐Santos, Andreia Brandão, Luís Pedro Afonso, Andreia Miranda, Eduardo Ferreira, Beatriz Santos, Martina Gonçalves, Paula Lopes, Lúcio Lara Santos, André M. N. Silva, José Alexandre Ferreira
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2025-03-01
Serie:	Molecular Oncology
Soggetti:	cancer glycoproteome colorectal cancer E‐selectin metastasis secretin receptor
Accesso online:	https://doi.org/10.1002/1878-0261.13733
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