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L1210 Cells Overexpressing ABCB1 Drug Transporters Are Resistant to Inhibitors of the N- and O-glycosylation of Proteins

Overexpression of P-glycoprotein (P-gp, drug transporter) in neoplastic cells is the most frequently observed molecular cause of multidrug resistance. Here, we show that the overexpression of P-gp in L1210 cells leads to resistance to tunicamycin and benzyl 2-acetamido-2-deoxy-α-d-galactopyranoside...

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Autori principali: Lucia Pavlikova, Mario Seres, Milan Hano, Viera Bohacova, Ivana Sevcikova, Tomas Kyca, Albert Breier, Zdena Sulova
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2017-07-01
Serie:Molecules
Soggetti:
L1210 cells
P-glycoprotein
multidrug resistance
N-glycosylation
O-glycosylation
tunicamycin
benzyl 2-acetamido-2-deoxy-α-
">d-galactopyranoside
ubiquitination
Accesso online:https://www.mdpi.com/1420-3049/22/7/1104
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