Optimization and transfer of robust primary drying protocols for biopharmaceuticals through lyophilization process modeling

Abstract Lyophilization, or freeze-drying, is a widespread process for stabilizing (bio)pharmaceutical products. The primary drying phase is resource-intensive, making its optimization a focal point for improving economic and environmental sustainability. Mechanistic modeling of the primary drying p...

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Hauptverfasser:	Brecht Vanbillemont, Andrea Arsiccio, Tim Menzen, Andrea Hawe
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	SpringerOpen 2025-06-01
Schriftenreihe:	AAPS Open
Schlagworte:	Biopharmaceuticals Lyophilization Process transfer Process robustness Mechanistic modelling Process optimization
Online-Zugang:	https://doi.org/10.1186/s41120-025-00115-5
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