Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically

Cyclic five-membered disulfides (1,2-dithiolanes) have been reported either as nonspecific redox motifs, or as highly specific cellular probes for thioredoxin reductase (TrxR). Here the authors show that 1,2-dithiolane probes are nonspecifically reduced by a range of thiol reductants and are not sen...

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Autori principali:	Jan G. Felber, Lena Poczka, Karoline C. Scholzen, Lukas Zeisel, Martin S. Maier, Sander Busker, Ulrike Theisen, Christina Brandstädter, Katja Becker, Elias S. J. Arnér, Julia Thorn-Seshold, Oliver Thorn-Seshold
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2022-04-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-022-29136-4
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