Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus

Enzymes in the thiol redox systems of microbial pathogens are promising targets for drug development. In this study we characterized the thioredoxin reductase (TrxR) selenoproteins from Brugia malayi and Onchocerca volvulus, filarial nematode parasites and causative agents of lymphatic filariasis an...

Полное описание

Библиографические подробности

Главные авторы:	Francesca Fata, Radosveta Gencheva, Qing Cheng, Rachel Lullo, Matteo Ardini, Ilaria Silvestri, Federica Gabriele, Rodolfo Ippoliti, Christina A. Bulman, Judy A. Sakanari, David L. Williams, Elias S.J. Arnér, Francesco Angelucci
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2022-05-01
Серии:	Redox Biology
Предметы:	Thioredoxin reductase Glutaredoxin Selenocysteine X-ray crystallography Auranofin Thioredoxin reductase inhibitor
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2213231722000507
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!