A Highly Selective GSK-3β Inhibitor CHIR99021 Promotes Osteogenesis by Activating Canonical and Autophagy-Mediated Wnt Signaling

The discovery and application of small molecules is one of the practical strategies of safe osteogenic drugs. The small molecule CHIR99021 (C91) is a highly specific, safe, and most effective GSK-3β Inhibitor. This study found that it efficiently activates the canonical Wnt signaling of bone marrow...

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Principais autores:	Bo Wang, Saima Khan, Pengtao Wang, Xiaofang Wang, Yangxi Liu, Jingjing Chen, Xiaolin Tu
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2022-07-01
סדרה:	Frontiers in Endocrinology
נושאים:	CHIR99021 Wnt/β-catenin signaling autophagy integrated 3D printing PCL scaffold osteoporosis
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fendo.2022.926622/full
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