CRISPR-Cas9 Editing Induces Loss of Heterozygosity in the Pathogenic Yeast Candida parapsilosis

ABSTRACT Genetic manipulation is often used to study gene function. However, unplanned genome changes (including single nucleotide polymorphisms [SNPs], aneuploidy, and loss of heterozygosity [LOH]) can affect the phenotypic traits of the engineered strains. Here, we compared the effect of classical...

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Autors principals:	Lisa Lombardi, Sean A. Bergin, Adam Ryan, Evelyn Zuniga-Soto, Geraldine Butler
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2022-12-01
Col·lecció:	mSphere
Matèries:	CRISPR-Cas9 Candida parapsilosis loss of heterozygosity genome editing
Accés en línia:	https://journals.asm.org/doi/10.1128/msphere.00393-22
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