CRISPR-Cas9 Editing Induces Loss of Heterozygosity in the Pathogenic Yeast Candida parapsilosis
ABSTRACT Genetic manipulation is often used to study gene function. However, unplanned genome changes (including single nucleotide polymorphisms [SNPs], aneuploidy, and loss of heterozygosity [LOH]) can affect the phenotypic traits of the engineered strains. Here, we compared the effect of classical...
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| Principais autores: | , , , , |
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| 格式: | Artigo |
| 语言: | Inglês |
| 出版: |
American Society for Microbiology
2022-12-01
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| 丛编: | mSphere |
| 主题: | |
| 在线阅读: | https://journals.asm.org/doi/10.1128/msphere.00393-22 |
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