ClpC1-targeting peptide natural products differentially dysregulate the proteome of Mycobacterium tuberculosis

Abstract Targeting the protein quality control system in Mycobacterium tuberculosis represents a promising and underexplored opportunity for antibiotic development. The ClpC1:ClpP1P2 protease is an essential component of the system that mediates both regulatory and stress-related protein degradation...

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Үндсэн зохиолчид:	Isabel K. Barter, Max J. Bedding, Julia Leodolter, Joshua W. C. Maxwell, Paige M. E. Hawkins, Maxwell T. Stevens, Matthew B. McNeil, William J. Jowsey, Trixie Wang, Diana Quan, Sabryna Junker, Manuela Flórido, Daniel Hesselson, Gregory M. Cook, Tim Clausen, Warwick J. Britton, Mark Larance, Richard J. Payne
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2026-01-01
Цуврал:	Nature Communications
Онлайн хандалт:	https://doi.org/10.1038/s41467-026-68423-2
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!