ClpC1-targeting peptide natural products differentially dysregulate the proteome of Mycobacterium tuberculosis

Abstract Targeting the protein quality control system in Mycobacterium tuberculosis represents a promising and underexplored opportunity for antibiotic development. The ClpC1:ClpP1P2 protease is an essential component of the system that mediates both regulatory and stress-related protein degradation...

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Bibliografiske detaljer

Principais autores:	Isabel K. Barter, Max J. Bedding, Julia Leodolter, Joshua W. C. Maxwell, Paige M. E. Hawkins, Maxwell T. Stevens, Matthew B. McNeil, William J. Jowsey, Trixie Wang, Diana Quan, Sabryna Junker, Manuela Flórido, Daniel Hesselson, Gregory M. Cook, Tim Clausen, Warwick J. Britton, Mark Larance, Richard J. Payne
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2026-01-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-026-68423-2
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