Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests.

The spindle checkpoint is a mitotic surveillance system which ensures equal segregation of sister chromatids. It delays anaphase onset by inhibiting the action of the E3 ubiquitin ligase known as the anaphase promoting complex or cyclosome (APC/C). Mad3/BubR1 is a key component of the mitotic checkp...

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Principais autores:	Judith Zich, Karen May, Konstantinos Paraskevopoulos, Onur Sen, Heather M Syred, Sjaak van der Sar, Hitesh Patel, James J Moresco, Ali Sarkeshik, John R Yates, Juri Rappsilber, Kevin G Hardwick
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2016-02-01
Colecção:	PLoS Genetics
Acesso em linha:	https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005834&type=printable
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