Conformational dynamics of a nicotinic receptor neurotransmitter site

Agonists enhance receptor activity by providing net-favorable binding energy to active over resting conformations, with efficiency (η) linking binding energy to gating. Previously, we showed that in nicotinic receptors, η-values are grouped into five structural pairs, correlating efficacy and affini...

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Bibliografiske detaljer
Main Authors: Mrityunjay Singh, Dinesh C Indurthi, Lovika Mittal, Anthony Auerbach, Shailendra Asthana
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2024-12-01
Serier:eLife
Fag:
nicotinic receptor
ion channel
allostery
Online adgang:https://elifesciences.org/articles/92418
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