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TREM1–NLRP3–driven pyroptosis in sepsis-associated acute kidney injury (AKI) with parallel autophagy changes

Abstract Sepsis-associated acute kidney injury (SAKI) is a leading cause of critical illness and death, yet its upstream drivers remain unclear. Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies innate immune signaling. We investigated whether TREM-1 acts upstream of the NLRP3 infl...

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Principais autores: Xudong Liu, Qian Chen, Xiangyu Chen, Yaqi Wang, Junping Fan, Xinlun Tian, Xinjie Xu, Longxiang Su
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Portfolio 2026-03-01
סדרה:Scientific Reports
נושאים:
Triggering receptor expressed on myeloid cells-1 (TREM-1)
NLRP3 inflammasome
pyroptosis
autophagy
sepsis-associated acute kidney injury
גישה מקוונת:https://doi.org/10.1038/s41598-026-40893-w
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