TREM1–NLRP3–driven pyroptosis in sepsis-associated acute kidney injury (AKI) with parallel autophagy changes

Abstract Sepsis-associated acute kidney injury (SAKI) is a leading cause of critical illness and death, yet its upstream drivers remain unclear. Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies innate immune signaling. We investigated whether TREM-1 acts upstream of the NLRP3 infl...

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Autores principales:	Xudong Liu, Qian Chen, Xiangyu Chen, Yaqi Wang, Junping Fan, Xinlun Tian, Xinjie Xu, Longxiang Su
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-03-01
Colección:	Scientific Reports
Materias:	Triggering receptor expressed on myeloid cells-1 (TREM-1) NLRP3 inflammasome pyroptosis autophagy sepsis-associated acute kidney injury
Acceso en línea:	https://doi.org/10.1038/s41598-026-40893-w
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