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Sirtuins regulate macrophage polarization in heart failure: Metabolic reprogramming, epigenetic regulation, and immune cell interactions

Heart failure (HF) is an end-stage cardiovascular syndrome caused by structural or functional cardiac abnormalities. Its high morbidity and mortality underscore the urgent need for novel therapeutic strategies. In recent years, the dynamic regulatory mechanisms underlying macrophage polarization in...

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Principais autores: Ruifang Lin, Yun Zhu, Yongjun Liu, Zhihua Guo, Jiaming Wei, Ya Li, Yunfeng Yu
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-10-01
Serier:Pharmacological Research
Fag:
Sirtuins
Macrophage polarization
Heart failure
Metabolic reprogramming
Epigenetic regulation
Immune cell interaction
Online adgang:http://www.sciencedirect.com/science/article/pii/S1043661825003615
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