High thrombin activity associated with crohn’s disease induces microbiota pathogenicity contributing to mucosal inflammation

Thrombin is a serine protease produced by the intestinal epithelium that contributes to mucosal homeostasis by limiting microbial encroachment. In Crohn's disease, mucosal thrombin activity is markedly increased, suggesting a role in disease pathophysiology. We hypothesized that excessive luminal th...

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Autors principals:	Guillaume Le Cosquer, Melissa Pannier, Julie Thevenin, Laura Guiraud, Melissa David, Alexia Dumas, Elodie Meunier, Perrine Rousset, Simone Palese, Carmine Giorgio, Louis Buscail, Barbara Bournet, Cyrielle Gilletta, Adrian Culetto, Cindy Canivet, Etienne Buscail, Caroline Camaré, Laurent Alric, Céline Deraison, Nathalie Vergnolle, Jean-Paul Motta
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis Group 2026-12-01
Col·lecció:	Gut Microbes
Matèries:	Crohn's disease thrombin host–microbiota interactions dysbiosis biofilms mucosal inflammation
Accés en línia:	https://www.tandfonline.com/doi/10.1080/19490976.2026.2687903
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