High thrombin activity associated with crohn’s disease induces microbiota pathogenicity contributing to mucosal inflammation

Thrombin is a serine protease produced by the intestinal epithelium that contributes to mucosal homeostasis by limiting microbial encroachment. In Crohn's disease, mucosal thrombin activity is markedly increased, suggesting a role in disease pathophysiology. We hypothesized that excessive luminal th...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Guillaume Le Cosquer, Melissa Pannier, Julie Thevenin, Laura Guiraud, Melissa David, Alexia Dumas, Elodie Meunier, Perrine Rousset, Simone Palese, Carmine Giorgio, Louis Buscail, Barbara Bournet, Cyrielle Gilletta, Adrian Culetto, Cindy Canivet, Etienne Buscail, Caroline Camaré, Laurent Alric, Céline Deraison, Nathalie Vergnolle, Jean-Paul Motta
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Taylor & Francis Group 2026-12-01
Σειρά:	Gut Microbes
Θέματα:	Crohn's disease thrombin host–microbiota interactions dysbiosis biofilms mucosal inflammation
Διαθέσιμο Online:	https://www.tandfonline.com/doi/10.1080/19490976.2026.2687903
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