Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target.

The human pathogen Mycobacterium tuberculosis is the causative agent of pulmonary tuberculosis (TB), a disease with high worldwide mortality rates. Current treatment programs are under significant threat from multi-drug and extensively-drug resistant strains of M. tuberculosis, and it is essential t...

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Prif Awduron:	Sudagar S Gurcha, Veeraraghavan Usha, Jonathan A G Cox, Klaus Fütterer, Katherine A Abrahams, Apoorva Bhatt, Luke J Alderwick, Robert C Reynolds, Nicholas J Loman, VijayaShankar Nataraj, Carlos Alemparte, David Barros, Adrian J Lloyd, Lluis Ballell, Judith V Hobrath, Gurdyal S Besra
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Public Library of Science (PLoS) 2014-01-01
Cyfres:	PLoS ONE
Mynediad Ar-lein:	https://doi.org/10.1371/journal.pone.0113568
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