PTIR1 acts as an isoform of DDX58 and promotes tumor immune resistance through activation of UCHL5

Summary: Cancer evades host immune surveillance by virtue of poor immunogenicity. Here, we report an immune suppressor, designated as PTIR1, that acts as a promotor of tumor immune resistance. PTIR1 is selectively induced in human cancers via alternative splicing of DDX58 (RIG-I), and its induction...

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Bibliografski detalji

Glavni autori:	Jia Song, Yang Liu, Yue Yin, Hui Wang, Xin Zhang, Yang Li, Xuyang Zhao, Guangze Zhang, Xiangyan Meng, Yan Jin, Dan Lu, Yuxin Yin
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2023-11-01
Serija:	Cell Reports
Teme:	CP: Immunology CP: Cancer
Online pristup:	http://www.sciencedirect.com/science/article/pii/S2211124723014006
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