CoA‐dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases

Abstract PKAN, CoPAN, MePAN, and PDH‐E2 deficiency share key phenotypic features but harbor defects in distinct metabolic processes. Selective damage to the globus pallidus occurs in these genetic neurodegenerative diseases, which arise from defects in CoA biosynthesis (PKAN, CoPAN), protein lipoyla...

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Bibliografische gegevens

Hoofdauteurs:	Roald A Lambrechts, Hein Schepers, Yi Yu, Marianne van der Zwaag, Kaija J Autio, Marcel A Vieira‐Lara, Barbara M Bakker, Marina A Tijssen, Susan J Hayflick, Nicola A Grzeschik, Ody CM Sibon
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Springer Nature 2019-11-01
Reeks:	EMBO Molecular Medicine
Onderwerpen:	4′‐phosphopantetheinylation Coenzyme A mtACP NBIA NDUFAB1
Online toegang:	https://doi.org/10.15252/emmm.201910488
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