A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis.

Pantothenate Kinase-Associated Neurodegeneration (PKAN) is a neurodegenerative disorder with a poorly understood molecular mechanism. It is caused by mutations in Pantothenate Kinase, the first enzyme in the Coenzyme A (CoA) biosynthetic pathway. Here, we developed a Drosophila model of PKAN (tim-fb...

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Váldodahkkit:	Varun ePandey, Hagit eTurm, Uriya eBekenstein, Sagiv eShifman, Sebastian eKadener
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Frontiers Media S.A. 2013-09-01
Ráidu:	Frontiers in Cellular Neuroscience
Fáttát:	Drosophila circadian NBIA PKAN PanK CoA
Liŋkkat:	http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00146/full
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