Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity.
Viruses have evolved a plethora of mechanisms to target host antiviral responses. Here, we propose a yet uncharacterized mechanism of immune regulation by the orthomyxovirus Thogoto virus (THOV) ML protein through engaging general transcription factor TFIIB. ML generates a TFIIB depleted nuclear env...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science (PLoS)
2018-04-01
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| Schriftenreihe: | PLoS Pathogens |
| Online-Zugang: | http://europepmc.org/articles/PMC5927403?pdf=render |
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