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BRCA1, BRCA2, and TP53 germline and somatic variants and clinicopathological characteristics of Brazilian patients with epithelial ovarian cancer

Abstract Background Approximately 3/4 of ovarian cancers are diagnosed in advanced stages, with the high‐grade epithelial ovarian carcinoma (EOC) accounting for 90% of the cases. EOC present high genomic instability and somatic loss‐of‐function variants in genes associated with homologous recombinat...

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Principais autores: Caroline Stahnke Richau, Nicole de Miranda Scherer, Bruna Palma Matta, Elvismary Molina deArmas, Fábio Carvalho deBarros Moreira, Anke Bergmann, Claudia Bessa Pereira Chaves, Mariana Boroni, Anna Claudia Evangelista dosSantos, Miguel Angelo Martins Moreira
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2024-02-01
Serier:Cancer Medicine
Fag:
BRCA1
BRCA2
homologous recombination repair pathway
ovarian cancer
somatic mutation
TP53
Online adgang:https://doi.org/10.1002/cam4.6729
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