Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery
Abstract Linear ubiquitination is a distinct type of ubiquitination that involves attaching a head-to-tail polyubiquitin chain to a substrate protein. Early studies found that linear ubiquitin chains are essential for the TNFα- and IL-1-mediated NF-κB signaling pathways. However, recent studies have...
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2023-11-01
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| coleção: | Cell Communication and Signaling |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1186/s12964-023-01239-5 |
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