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Targeted Protein Degradation Systems: Controlling Protein Stability Using E3 Ubiquitin Ligases in Eukaryotic Species

This review explores various methods for modulating protein stability to achieve target protein degradation, which is a crucial aspect in the study of biological processes and drug design. Thirty years have passed since the introduction of heat-inducible degron cells utilizing the N-end rule, and me...

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Autori principali: Yoshitaka Ogawa, Taisei P. Ueda, Keisuke Obara, Kohei Nishimura, Takumi Kamura
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2024-01-01
Serie:Cells
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Accesso online:https://www.mdpi.com/2073-4409/13/2/175
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