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Allosteric Inhibitors of Zika Virus NS2B-NS3 Protease Targeting Protease in “Super-Open” Conformation

The Zika virus (ZIKV), a member of the Flaviviridae family, is considered a major health threat causing multiple cases of microcephaly in newborns and Guillain-Barré syndrome in adults. In this study, we targeted a transient, deep, and hydrophobic pocket of the “super-open” conformation of ZIKV NS2B...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Ittipat Meewan, Sergey A. Shiryaev, Julius Kattoula, Chun-Teng Huang, Vivian Lin, Chiao-Han Chuang, Alexey V. Terskikh, Ruben Abagyan
Hōputu: Artigo
Reo:Inglês
I whakaputaina: MDPI AG 2023-04-01
Rangatū:Viruses
Ngā marau:
Urunga tuihono:https://www.mdpi.com/1999-4915/15/5/1106
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