Allosteric Inhibitors of Zika Virus NS2B-NS3 Protease Targeting Protease in “Super-Open” Conformation

The Zika virus (ZIKV), a member of the Flaviviridae family, is considered a major health threat causing multiple cases of microcephaly in newborns and Guillain-Barré syndrome in adults. In this study, we targeted a transient, deep, and hydrophobic pocket of the “super-open” conformation of ZIKV NS2B...

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Principais autores:	Ittipat Meewan, Sergey A. Shiryaev, Julius Kattoula, Chun-Teng Huang, Vivian Lin, Chiao-Han Chuang, Alexey V. Terskikh, Ruben Abagyan
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2023-04-01
Serija:	Viruses
Teme:	Zika virus protease inhibitors allosteric inhibitors Zika virus NS2B-NS3 protease super-open conformation
Online dostop:	https://www.mdpi.com/1999-4915/15/5/1106
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