In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds

The calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) activates CAMK1, CAMK4, AMPK, and AKT, leading to numerous physiological responses. The deregulation of CAMKK2 is linked to several diseases, suggesting the utility of CAMKK2 inhibitors for oncological, metabolic and inflammatory indi...

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Главные авторы:	Sean N. O’Byrne, John W. Scott, Joseph R. Pilotte, André da S. Santiago, Christopher G. Langendorf, Jonathan S. Oakhill, Benjamin J. Eduful, Rafael M. Couñago, Carrow I. Wells, William J. Zuercher, Timothy M. Willson, David H. Drewry
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2020-01-01
Серии:	Molecules
Предметы:	kinase camkk2 sto-609 chemical probes oncology kinase inhibitors
Online-ссылка:	https://www.mdpi.com/1420-3049/25/2/325
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