Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase
Pyruvate dehydrogenase kinases (PDHKs) are non-canonical serine/threonine kinases that regulate the pyruvate dehydrogenase complex. Given their central role in metabolism, dysregulation of PDHKs has been linked with a broad variety of pathological conditions, such as cardiovascular disease, diabetes...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Elsevier
2025-04-01
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| Collection: | SLAS Discovery |
| Sujets: | |
| Accès en ligne: | http://www.sciencedirect.com/science/article/pii/S2472555225000206 |
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