Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase

Pyruvate dehydrogenase kinases (PDHKs) are non-canonical serine/threonine kinases that regulate the pyruvate dehydrogenase complex. Given their central role in metabolism, dysregulation of PDHKs has been linked with a broad variety of pathological conditions, such as cardiovascular disease, diabetes...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Mya D. Gough, Matthew B. Robers, Cesear R. Corona, Ranjit K. Mehta, Mukesh K. Nyati, Peter L. Toogood
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2025-04-01
סדרה:	SLAS Discovery
נושאים:	Pyruvate dehydrogenase kinase Target engagement NanoBRET
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S2472555225000206
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!