Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway

Summary: Pathological hyperphosphorylation and aggregation of tau (pTau) and neuroinflammation, driven by interleukin-1β (IL-1β), are the major hallmarks of tauopathies. Here, we show that pTau primes and activates IL-1β. First, RNA-sequence analysis suggests paired-helical filaments (PHFs) from hum...

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主要な著者:	Shanya Jiang, Nicole M. Maphis, Jessica Binder, Devon Chisholm, Lea Weston, Walter Duran, Crina Peterson, Amber Zimmerman, Michael A. Mandell, Stephen D. Jett, Eileen Bigio, Changiz Geula, Nikolaos Mellios, Jason P. Weick, Gary A. Rosenberg, Eicke Latz, Michael T. Heneka, Kiran Bhaskar
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2021-09-01
シリーズ:	Cell Reports
主題:	tauopathies tau MAPT IL-1β neuroinflammation microglia
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2211124721011694
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