Structural insight into inhibitor of apoptosis proteins recognition by a potent divalent smac-mimetic.

Genetic alterations enhancing cell survival and suppressing apoptosis are hallmarks of cancer that significantly reduce the efficacy of chemotherapy or radiotherapy. The Inhibitor of Apoptosis Protein (IAP) family hosts conserved proteins in the apoptotic pathway whose over-expression, frequently fo...

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書誌詳細

主要な著者:	Federica Cossu, Mario Milani, Patrice Vachette, Francesca Malvezzi, Serena Grassi, Daniele Lecis, Domenico Delia, Carmelo Drago, Pierfausto Seneci, Martino Bolognesi, Eloise Mastrangelo
フォーマット:	Artigo
言語:	Inglês
出版事項:	Public Library of Science (PLoS) 2012-01-01
シリーズ:	PLoS ONE
オンライン･アクセス:	http://europepmc.org/articles/PMC3499469?pdf=render
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