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Design, Synthesis and Cholinesterase Inhibitory Activity of Novel 1,3,4-Thiadiazole Derivatives

Inhibition of the cholinesterases (AChE and BChE) plays a pivotal role in the symptomatic treatment of Alzheimer’s disease. The present study reports the synthesis and anticholinesterase activity of five novel thiadiazole analogs in search of anti-Alzheimer agents. The structures of the newly synthe...

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Principais autores: Ulviye Acar Çevik, Mesut Isık, Zafer Asım Kaplancıklı, Şükrü Beydemir, Betül Kaya, Bilge Çiftci
Formato: Artigo
Idioma:Inglês
Publicado em: Sivas Cumhuriyet Üniversitesi 2024-09-01
coleção:Cumhuriyet Science Journal
Assuntos:
acetylcholinesterase
butyrylcholinesterase
cholinesterase inhibitors
1
3
4-thiadiazole
alzheimer’s disease
Acesso em linha:https://dergipark.org.tr/en/download/article-file/3782719
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