Design, Synthesis, In Silico Absorption, Distribution, Metabolism, and Elimination and Molecular Docking Studies of Thiazole‐Based Furan Derivatives, and Their Biological Evaluation for Alzheimer Disease Therapy

Herein, a series of novel 5‐hydroxymethylfuran incorporated thiazole‐based furan derivatives are synthesized and characterized. The in vitro inhibitory potentials of the derivatives against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are evaluated. In addition, the inhibitory potent...

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Bibliografski detalji

Glavni autori:	Abdüllatif Karakaya, Ulviye Acar Çevik, Betül Kaya, Bilge Çiftçi, Adem Necip, Mesut Işık, Şükrü Beydemir, Yusuf Özkay, Zafer Asım Kaplancıklı
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley-VCH 2025-12-01
Serija:	ChemistryOpen
Teme:	Alzheimer's disease cholinesterase inhibitors furan molecular docking thiazole
Online pristup:	https://doi.org/10.1002/open.202500305
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