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Short incubation periods of atypical H-type BSE in cattle with EK211 and KK211 prion protein genotypes after intracranial inoculation

In 2006, a case of atypical H-type BSE (H-BSE) was found to be associated with a germline mutation in the PRNP gene that resulted in a lysine substitution for glutamic acid at codon 211 (E211K). The E211K amino acid substitution in cattle is analogous to E200K in humans, which is associated with the...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Eric D. Cassmann, Alexis J. Frese, Kelsey A. Becker, Justin J. Greenlee
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2023-11-01
Schriftenreihe:Frontiers in Veterinary Science
Schlagworte:
prion diseases
prion protein
PRNP
E211K
H-BSE
atypical BSE
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fvets.2023.1301998/full
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