Tau modulation through AAV9 therapy augments Akt/Erk survival signalling in glaucoma mitigating the retinal degenerative phenotype

Abstract The microtubule-associated protein Tau is a key player in various neurodegenerative conditions, including Alzheimer's disease (AD) and Tauopathies, where its hyperphosphorylation disrupts neuronal microtubular lattice stability. Glaucoma, a neurodegenerative disorder affecting the retina, l...

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Detalhes bibliográficos

Principais autores:	Kanishka Pushpitha Maha Thananthirige, Nitin Chitranshi, Devaraj Basavarajappa, Rashi Rajput, Mojdeh Abbasi, Viswanthram Palanivel, Veer Bala Gupta, Joao A. Paulo, Maya Koronyo-Hamaoui, Mehdi Mirzaei, Stuart L. Graham, Vivek Gupta
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-06-01
coleção:	Acta Neuropathologica Communications
Assuntos:	Glaucoma Tau Retinal ganglion cells Microtubules Neurodegeneration Intraocular pressure
Acesso em linha:	https://doi.org/10.1186/s40478-024-01804-0
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