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Tonic GABAA receptor currents in Cerebellar Purkinje cells of wild-type and DMDmdx mice

Abstract Cerebellar Purkinje cells (PCs) fire spontaneously and depend heavily on inhibition to modify their activity. While phasic inhibition is well-described in PCs, the presence and mechanisms of tonic inhibitory currents, low amplitude currents resulting from ambient GABA acting upon extrasynap...

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Principais autores: Shaarang Mitra, Shailesh N. Khatri, Jason R. Pugh
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-12-01
Serier:Scientific Reports
Fag:
GABAA
Tonic current
Inhibition
Purkinje
DMD
mdx
Online adgang:https://doi.org/10.1038/s41598-025-31919-w
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