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A pan-cancer single cell landscape reveals heterogeneity and functional diversity of double-negative T cells

Abstract Background Double-Negative T (DNT) cells, lacking both CD4 and CD8 expression, play critical roles in cancer immunology, and have garnered increasing attention in cancer research. However, their heterogeneity and functional diversity within the tumor microenvironment (TME) remain underexplo...

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Principais autores: Qing Hao, Tao Zhou, Huayun Yan, Zhixiang Ren, Wei Mao, Li-Bin Huang, Yue-yun Chen, Yuelan Wang, Minqin Xiao, Yajiao He, Xuyang Xia, Jing Wu, Wei-Han Zhang, Hai-Ning Chen, Maoxiang Qian, Feng Zhang, Li Yang, Lunzhi Dai, Huiyuan Zhang, Canhua Huang, Yang Shu, Yu Xu, Yang Luo, Yong Peng, Heng Xu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-01-01
Colecção:Molecular Cancer
Assuntos:
Single-cell RNA sequencing
Pan-cancer
Double-Negative T cell
Γδ T cell
Tumor microenvironment
Immunotherapy
Acesso em linha:https://doi.org/10.1186/s12943-025-02548-8
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