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Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis

Summary: Epigenetic alterations are especially important in necrotizing enterocolitis (NEC). Here, we reported that histone deacetylase 8 (HDAC8) plays a previously unknown role in modulating arginine metabolism via acetylation of histone 3 lysine 9 (acetyl-H3K9) regulation during the pathogenesis o...

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Main Authors: Ting Guo, Shaohua Hu, Weijue Xu, Jin Zhou, Feng Chen, Tingting Gao, Wenqian Qu, Faling Chen, Zhibao Lv, Li Lu
Format: Artigo
Language:Inglês
Published: Elsevier 2023-06-01
Series:iScience
Subjects:
Biological sciences
Genetics
Molecular biology
Molecular Genetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223009598
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