Maintenance of graft tissue–resident Foxp3+ cells is necessary for lung transplant tolerance in mice

Mechanisms that mediate allograft tolerance differ between organs. We have previously shown that Foxp3+ T cell–enriched bronchus-associated lymphoid tissue (BALT) is induced in tolerant murine lung allografts and that these Foxp3+ cells suppress alloimmune responses locally and systemically. Here, w...

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Bibliografische gegevens
Hoofdauteurs: Wenjun Li, Yuriko Terada, Yun Zhu Bai, Yuhei Yokoyama, Hailey M. Shepherd, Junedh M. Amrute, Amit I. Bery, Zhiyi Liu, Jason M. Gauthier, Marina Terekhova, Ankit Bharat, Jon H. Ritter, Varun Puri, Ramsey R. Hachem, Hēth R. Turnquist, Peter T. Sage, Alessandro Alessandrini, Maxim N. Artyomov, Kory J. Lavine, Ruben G. Nava, Alexander S. Krupnick, Andrew E. Gelman, Daniel Kreisel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2025-05-01
Reeks:The Journal of Clinical Investigation
Onderwerpen:
Immunology
Transplantation
Online toegang:https://doi.org/10.1172/JCI178975
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