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Multilocus inherited neoplasia allele syndrome (MINAS) in a Turkish cohort: molecular insights and clinical relevance for precision oncology

BackgroundMultilocus Inherited Neoplasia Allele Syndrome (MINAS) describes individuals who harbor pathogenic or likely pathogenic (LP/P) germline variants in two or more distinct cancer predisposition genes. With the broader implementation of next-generation sequencing (NGS) and multigene panel test...

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Autori principali: Taha Bahsi, Serhat Seyhan, Kaan Helvaci, Umut Demirci, Irem Bilgetekin, Selami Bayram, Mehmet Akif Ozturk, Fatih Aydogan, Serkan Keskin, Kezban Pilanci, Nur Sener, Murat Tatlı, Hakan Harputluoglu, Esat Namal, Aysegul Kargi, Mukremin Uysal, Mahmut Ilhan, Cihan Erol, Naziyet Kose, Kerem Okutur, Halit Karaca, Erkan Dogan, Veli Berk, Ahmet Siyar Ekinci, Mustafa Ozdogan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2025-12-01
Serie:Frontiers in Pharmacology
Soggetti:
MINAS
germline variants
multigene panel
BRCA
Turkish cohort
hereditary cancer
Accesso online:https://www.frontiersin.org/articles/10.3389/fphar.2025.1672774/full
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