Dissolvable silk microneedles delivering minocycline-loaded ZIF-8 nanoparticles for targeted modulation of sebocyte metabolism and improved acne therapy

Abstract Background Acne Vulgaris (AV) lesions exhibit an acidic, sebum-rich, and inflammation-prone microenvironment in which conventional minocycline therapy is constrained by the stratum-corneum barrier and systemic exposure. Here, we present the fabrication and application of dissolvable silk fi...

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Egile Nagusiak:	Xuefan Yang, Dandan Ruan, Feng Ye, Xinlan Qiu, Sitong Li, Lei Huang, Christos C Zouboulis, Xiaohui Mo, Xiping Jiang, Qiang Ju
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2026-03-01
Saila:	Journal of Nanobiotechnology
Gaiak:	Acne vulgaris Sebocyte ZIF-8 Minocycline Silk Fibroin Microneedle
Sarrera elektronikoa:	https://doi.org/10.1186/s12951-026-04221-8
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