Paeoniflorin mitigates insulin-like growth factor 1-induced lipogenesis and inflammation in human sebocytes by inhibiting the PI3K/Akt/FoxO1 and JAK2/STAT3 signaling pathways

Abstract Insulin-like growth factor-1 (IGF-1) is considered as a pathogenic factor contributing to sebaceous gland dysfunction, which leads to acne vulgaris. Paeoniflorin (Pae), a bioactive monomer derived from total glycosides of paeony, has shown potential in treating various diseases. However, it...

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Автори:	Chuanchuan Cai, Si Liu, Yufeng Liu, Shaobin Huang, Shiya Lu, Fang Liu, Xiaohua Luo, Christos C. Zouboulis, Ge Shi
Формат:	Artigo
Мова:	Inglês
Опубліковано:	SpringerOpen 2024-10-01
Серія:	Natural Products and Bioprospecting
Предмети:	Paeoniflorin Acne vulgaris Sebocytes Insulin-like growth factor-1
Онлайн доступ:	https://doi.org/10.1007/s13659-024-00478-4
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