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Mitochondrial transplant activates Ca2+/TFAP2A to promote hDPSCs-mediated dentin-pulp regeneration

Abstract Background The dentin-pulp complex (DPC) is composed of the odontoblastic layer and associated stromal components. It serves key functions in immunological homeostasis and tissue regeneration of dental tissues. Human dental pulp stem cells (hDPSCs) have emerged as pivotal cells for DPC rege...

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Principais autores: Peimeng Zhan, Xinfang Zhang, Zhuo Xie, Lingling Chen, Shuheng Huang, Qiting Huang, Zhengmei Lin, Runfu Wang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-03-01
Serier:Stem Cell Research & Therapy
Fag:
Mitochondrial transplantation
Human dental pulp stem cells
Odontoblast differentiation
Dentin-pulp complex regeneration
Tissue engineering
Online adgang:https://doi.org/10.1186/s13287-026-04949-y
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