Menaquinone-7 alleviates mitochondrial dysfunction and senescence in senile osteoporosis by targeting the PINK1-mediated mitophagy via PXR/ERK/CREB signaling pathway

Current therapeutic strategies for senile osteoporosis inadequately address its low-turnover pathology driven by mitochondrial dysfunction and cellular senescence. This study identifies menaquinone-7 (MK-7), a vitamin K2 isoform, as a novel therapeutic agent targeting mitochondrial homeostasis in se...

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Autores principales:	Yu Xu, Wencan Zhang, Wenpeng Xu, Shangzhi Li, Dingxin Zhang, Xiangyu Lin, Jincheng Liu, Qingyang Fu, Peijie Hu, Haipeng Si
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2026-06-01
Colección:	Journal of Pharmaceutical Analysis
Materias:	Senile osteoporosis Mitophagy Cellular senescence Menaquinone-7 (MK-7) PXR/ERK/CREB signaling Mitochondrial homeostasis
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2095177925002497
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