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Menaquinone-7 alleviates mitochondrial dysfunction and senescence in senile osteoporosis by targeting the PINK1-mediated mitophagy via PXR/ERK/CREB signaling pathway

Current therapeutic strategies for senile osteoporosis inadequately address its low-turnover pathology driven by mitochondrial dysfunction and cellular senescence. This study identifies menaquinone-7 (MK-7), a vitamin K2 isoform, as a novel therapeutic agent targeting mitochondrial homeostasis in se...

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Auteurs principaux: Yu Xu, Wencan Zhang, Wenpeng Xu, Shangzhi Li, Dingxin Zhang, Xiangyu Lin, Jincheng Liu, Qingyang Fu, Peijie Hu, Haipeng Si
Format: Artigo
Langue:Inglês
Publié: Elsevier 2026-06-01
Collection:Journal of Pharmaceutical Analysis
Sujets:
Senile osteoporosis
Mitophagy
Cellular senescence
Menaquinone-7 (MK-7)
PXR/ERK/CREB signaling
Mitochondrial homeostasis
Accès en ligne:http://www.sciencedirect.com/science/article/pii/S2095177925002497
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